Welcome at the Institute for Pharmacology and Toxicology
Welcome at the Institute for Pharmacology and Toxicology

Welcome on the web page of the Institute for Pharmacology and Toxicology!

The Institute for Pharmacology and Toxicology represents the department of pharmacology and toxicology in research and teaching.

It is located at the biomedical centre at the Venusberg campus of the university hospital Bonn.

Recent publication in Nature Cell Biology!

Brown adipose tissue (BAT) is essential for thermogenic regulation as well as energy expenditure and cardiometabolic health. However, there is a high medical need for regulators that increase the amount of BAT.

In this recent publication in Nature Cell Biology, we show that EPAC1 plays a crucial role in increasing the mass of BAT. Stimulators of EPAC1 enhance proliferation and differentiation of human brown fat tissue and organoids. 

Reverte-Salisa, L., Siddig, S., Hildebrand, S. et al. EPAC1 enhances brown fat growth and beige adipogenesis. Nat Cell Biol 26, 113–123 (2024). https://doi.org/10.1038/s41556-023-01311-9

Prof. Yongguo Li receives ERC Grant!

He was granted this funding for this cutting edge research in the field of lipid metabolism and how it can be influenced to increase calory consumption. 

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© Li

Publication in Nature

Brown adipose tissue (BAT) dissipates energy and promotes cardio-metabolic health. In this publication, Nieman et al identifiy inosine as novel tissue-messenger in brown fat (BAT). They show that treatment of mice with inosine increased BAT-dependent energy expenditure and induced “browning” of white adipose tissue. This work is funded by the DFG.

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© Michelle Y. Jaeckstein and Jörg Heeren, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

Niemann, B., Haufs-Brusberg, S., Puetz, L. et al. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022). https://doi.org/10.1038/s41586-022-05041-0

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