Welcome on the web page of the Institute for Pharmacology and Toxicology!
The Institute for Pharmacology and Toxicology represents the department of pharmacology and toxicology in research and teaching.
It is located at the biomedical centre at the Venusberg campus of the university hospital Bonn.
Publication in Nature
Brown adipose tissue (BAT) dissipates energy and promotes cardio-metabolic health. In this publication, Nieman et al identifiy inosine as novel tissue-messenger in brown fat (BAT). They show that treatment of mice with inosine increased BAT-dependent energy expenditure and induced “browning” of white adipose tissue. This work is funded by the DFG.
Niemann, B., Haufs-Brusberg, S., Puetz, L. et al. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022). https://doi.org/10.1038/s41586-022-05041-0