GPCR and purine signaling
G protein-coupled receptors regulate a plethora of physiological processes. Moreover, these receptors and their ligands are the targets for the majority of currently approved pharmaceuticals. We investigate GPCRs, their ligands and the associated signal transduction cascades primarily in the context of energy homeostasis, metabolism and the cardiovascular system.
In the picture above one can see immunocytochemical staining of primary murine white pre-adipocytes detected with a primary antibody against Gpr81 and a secondary antibody labelled with Alexa Fluor 647.
Here are some of our latest publications on this issue:
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A.
Cell Metab. 2020 Jul 7;32(1):56-70.e7. doi: 10.1016/j.cmet.2020.06.006.
RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation.
Klepac K, Yang J, Hildebrand S, Pfeifer A.
Mol Metab. 2019 Dec;30:173-183. doi: 10.1016/j.molmet.2019.09.015. Epub 2019 Oct 5.
The Gq signalling pathway inhibits brown and beige adipose tissue.
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.
Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895. PMID: 26955961
Contact
Prof. Dr. Alexander Pfeifer
Venusberg Campus 1
53127 Bonn