One Two
Prof. Dr. med. Alexander Pfeifer

Direktor
des Instituts für Pharmakologie und Toxikologie 
Rheinische Friedrich-Wilhelms-Universität Bonn
BMZ 2G014/15
Sigmund-Freud-Str. 25
D-53105 Bonn

alexander.pfeifer@uni-bonn.de

Tel: +49-228-287-51300/51302
Fax: +49-228-287-51301

 
Sie sind hier: Startseite Forschung/Arbeitsgruppen AG Pfeifer Publikationen

Ausgewählte Publikationen


  • Hoffmann LS, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer AW, Stasch JP, Bloch W, Friebe A, Heeren J, Pfeifer A. (2015) Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue, Nature Communications, DOI: 10.1038/ncomms8235
  • Gnad T, Scheibler S, von Kügelgen I, Scheele C, Kilic A, Glöde A, Hoffmann LS, Reverte L, Horn P, Mutlu S, El-Tayeb A, Kranz M, Deuther-Conrad W, Brust P,  Lidell ME, Betz M, Enerbäck S, Schrader J, Yegutkin GG, Müller CE, Pfeifer A (2014). Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature, doi: 10.1038/nature13816

  • Chen Y, Siegel F, Kipschull S, Haas B, Fröhlich H, Meister G, Pfeifer A.(2013) miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun. doi: 10.1038/ncomms2742 [fulltext]
  • Mitschke MM., Hoffmann LS., Gnad T., Scholz D., Kruithoff K., Mayer P., Haas B., Sassmann A., Pfeifer A., Kilic A. (2013). Increased cGMP promotes healthy expansion and browning of white adipose tissue. The FASEB Journal, January 9 [Epub ahead of print]
  • Jennissen K, Siegel F, Liebig-Gonglach M, Hermann MR, Kipschull S, van Dooren S, Kunz WS, Fässler R, Pfeifer A. (2012). A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes.Sci Signal. 2012 Aug 28;5(239):ra62. doi: 10.1126/scisignal.2002867.

  • Pfeifer A, Zimmermann K, Plank C. (2012). Magnetic nanoparticles for biomedical applications. Pharm Res. 2012 May;29(5):1161-4.

  • Trueck C, Zimmermann K, Mykhaylyk O, Anton M, Vosen S, Wenzel D, Fleischmann BK, Pfeifer A. (2012). Optimization of magnetic nanoparticle-assisted lentiviral gene transfer. Pharm Res. 2012 May;29(5):1255-69.

  • Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. (2010). Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts.Sci Signal. 2010 Dec 21;3(153):ra91.

  • Pfeifer A., Lim T., Zimmermann K. (2010). Lentivirus transgenesis. Methods Enzymol. 2010;477:3-15.

  • Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. (2010). Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes; 2010 May;59(5):1228-38. Epub 2010 Feb 25.

  • Pfeifer, A., Lehmann, H. (2010). Pharmacological Potential of RNAi - Focus on miRNA. Pharmacol Ther. 2010; Apr 11. Epub 2010 Apr 11.

  • Haas, B., Jennissen, K., Mayer, P., Scholz, D., Berriel Diaz, M., Bloch, W., Herzig, S., Fässler, R., Pfeifer A. (2009). Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Science Signaling 2009; Dec 1;2(99):ra78. Download des kostenlosen Volltexts von der englischen Version der Webseite  [abstract]  [summary] [podcast]

  • Hofmann, A., Wenzel, D., Becher, UM., Freitag, DF., Klein, AM., Eberbeck, D., Schulte, M., Zimmermann, K., Bergemann, C., Gleich, B., Roell, W., Weyh, T., Trahms, L., Nickenig, G., Fleischmann, BK., Pfeifer, A. (2009). Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles. Proc Natl Acad Sci U S A. 2009;106(1): 44-9

  • Pfeifer, A., Hofmann, A. (2009). Lentiviral transgenesis. Methods Mol Biol. 2009;530: 1-15

  • Massoumi, H., Kuphal, S., Hellerbrand, C., Haas, B., Wild, P., Spruss, T., Pfeifer, A., Fässler, R., Bosserhoff, AK. (2009). Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med. 2009;206(1):221-32

  •  Pfeifer, A., Eigenbrod, S., Al-Khadra, S., Hofmann, A., Mitteregger, G., Moser, M., Bertsch, U., & Kretzschmar, H. (2006). Lentivector-mediated RNAi efficiently suppresses PrP and prolongs survival of scrapie-infected mice. J Clin Invest. 2006;116(12):3204-10

  • Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A., & Fässler, R.  (2006). Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kB signalling Cell 125(4): 665-77.

  • Hofmann A., Kessler B., Ewerling S., Kabermann A., Brem G., Wolf E., Pfeifer A. (2005) Epigenetic Regulation of Lentiviral Transgene Vectors in a Large Animal Model. Mol Ther. 13(1): 59-66.

  • Pfeifer, A. (2004). Lentiviral transgenesis. Transgenic Res. 13(6):513-22

  • Hofmann, A., Zakhartchenko, V., Weppert, M., Sebald, H., Wenigerkind, H., Brem, G., Wolf, E., Pfeifer, A. (2004) Generation of Transgenic Cattle by Lentiviral Gene Transfer into Oocytes. Biol Reprod. 71(2):405-9.

  • Hofmann, A., Kessler, B., Ewerling, S., Weppert, M., Vogg, B., Stojkovic, M., Boelhauve, M., Brem, G., Wolf, E., Pfeifer, A. (2003). Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep. 4(11):1054-1058.

  • Pfeifer, A., Ikawa, M., Dayn, Y., & Verma, I.M. (2002). Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc. Natl. Acad. Sci. USA 99:2140-2145.

  • Pfeifer, A., & Verma, I.M. (2001). Gene therapy: Promises and problems. Annu. Rev. Genomics Hum. Genet. 2:177-211.

  • Pfeifer, A., Brandon, E. P., Kootstra, N., Gage, F.H., & Verma, I.M. (2001). Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo. Proc. Natl. Acad. Sci. USA 98:11450-11455.

  • Pfeifer, A., Wang, M., Kessler, T., Baranov, E., Cheresh, D., Hoffman, R.M., & Verma, I.M. (2001). Transduction of liver cells by lentiviral vectors: Analysis in living animals by fluorescence imaging. Mol. Ther. 3:319-322.

  • Pfeifer, A., Kessler, T., Cheresh, D., & Verma, I. (2000). Suppression of angiogenesis by lentiviral delivery of a non-catalytic fragment of Matrix-Metalloprotein-2. Proc. Natl. Acad. Sci. USA 97:12227-12232.

  • Pfeifer, A., Ruth, P., Dostmann, W., Klatt, P., Sausbier, M., & Hofmann, F. (1999). Structure and function of cGMP-dependent protein kinase. Rev. Physiol. Biochem. Pharmacol. 135: 105-149.

  • Aszódi, A.*,Pfeifer, A.*, Ahmad, M., Glauner, M., Zhou, X-H., Ny, L., Andersson, K-E., Kehrel,B., Offermanns, S., & Fässler, R. (1999). The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibtionof agonist-induced platelet aggregation but is dispensable for smooth-muscle function. EMBO J. 18: 37-48. (*contributed equally)

  • Pfeifer, A., Klatt, P., Massberg, S., Ny, L., Sausbier, M., Hirneiß, C., Wang, G.-X., Korth,M., Aszódi, A., Andersson, K.-E., Krombach, F., Mayerhofer, A., Ruth, P., Fässler, R., & Hofmann, F. (1998). Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J. 17: 3045-3051.

  • Pfeifer, A., Aszódi, A., Seidler, U., Ruth, P., Hofmann, F., & Fässler, R. (1996). Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274: 2082-2086.

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